To observe the clinical effect of Huangqin Xiebai San and Daige San in the treatment of post infection cough. Methods: A total of 120 cases of patients with post infection cough were randomly divided into two groups, each group of 60 people.The treatment group was treated by Huangqin Xiebai San and Daige San and the control group was treated by Chlorphenamine Maleate tablets and Codeine and Guaifenesin syrup. Both groups has been treating for 2weeks. Comparison the changes of symptoms and clinical efficacy of the two groups. Results: After 2 weeks of treatment, the total effective rate of the treatment group was 92.11% and that of the control group was76.32%(P<0.05) The TCM score of the treatment group was significantly lower than that of the control group (P<0.05). Conclusion: Huangqin Xiebai San and Daige San is effective in treating infection cough.