To observe the safety of Yangxin decoction and clozapine in the treatment of re-current schizophrenia. Methods: Sixty patients were recruited and randomly divided into 2 groups. The experimental group was treated by Yangxin decoction and clozapine and the control group by clozapine. The safety of the drug was observed after 4 weeks of treatment. TESS scale is used for safety evaluation. White blood cells, liver function, glutamic-pyruvic transaminase(ALT), electrocardiogram were monitored. Besides, dopamine D1 receptors and 5-HT receptor level in plasma were detected. Results: Twenty-two cases of adverse reaction from control group has improved and 24 cases of adverse reaction from the experimental group got better. The improvement of the experimental group is better than that of the control group in excitement or agitation, insomnia, blurred vision, and constipation. One case from experimental group recovered after 4 weeks of lower of white cells in baseline period. ALT had no abnormal conditions after 4 weeks. Electrocardiogram had no abnormal conditions. There were no significant differences at baseline, and after 4 weeks, there is no difference among the health group and the experimental group treatment group. The dopamine D1 receptor levels, 5-HT receptor levels of the negative group and positive group in four weekend were lower than that of healthy controls, and 5-HT receptor levels of negative symptoms group were lowest after 4 weeks of treatment. Conclusion: Yangxin decoction and clozapine can effectively improve the symptoms of recurrent Schizophrenia, especially for negative symptoms, and has great curative effect.