To establish viral pneumonia mouse models infected by influenza virus, and observe whether there is a specific intestinal pathological damage in the process of respiratory influenza virus infection, then discuss its application on the research of the theory “the lung and the large intestine being interior-exteriorly related” in Traditional Chinese Medicine. Methods: A total of 48 BALB/c mice were randomly divided into the normal group and the virus group. Influenza virus 50 μL 50 LD50 and mouse lung-adapted strain, was intranasally inoculated to the virus group. On the 3, 5 and 6 day of infection, HE staining was used to detect the pathologic changes /in lungs, large intestines, small intestines, hearts, livers and kidneys. In addition, blood biochemistry was used to detect the levels of aspertate aminotransferase(AST), alanine aminotransferase(ALT), urea nitrogen(BUN) in serum. Results: After infection, the lungs of the mice in the virus group showed obvious inflammatory pathological changes, and hyperemia edema, hemorrhage in the lung tissues aggravated with time; the arrangement of mucosal glands in the small intestines was disordered with the villus swelling and partial detachment, and the mucosa lamina propria was infiltrated with lots of inflammatory cells; the large intestine lamina propria and the muscular layer has been infiltrated with large number of inflammatory cells and the muscle layer glandular structures disappeared. However, the heart, liver and kidney had no obvious pathological changes, and the AST, ALT, BUN levels in the virus group showed no significant difference. Conclusion: The viral pneumonia mouse model infected with influenza virus exists specific immunologically pathological damage in the small intestine and the large intestine. It serves as an ideal model to study the Traditional Chinese Medicine theory “the Lung and the Large Intestine being interior-exteriorly related” and the related clinic treatment.