To explore the mechanism of Sangshen Shouwu Bunao granule on preventing dementia and provide data support on clinical treatment. Methods:To detect the changes of SOD, MDA and β-amyloid on Alzheimer Wistar rats after giving Sangshen Shouwu Bunao granule. Results:Sangshen Shouwu Bunao granule can promote the learning and memory capabilities of rats, increase SOD, decrease MDA level and down regulate amyloid β expression. Conclusion:Sangshen Shouwu Bunao granule can prevent Alzheimer’s disease. This is possibly because it can reduce β-amyloid in brain tissue, increase levels of SOD, and decrease MDA levels; thus to repair brain tissue damage.