In the year of 2015, WHO, APASL, AASLD and some academic organizations in China updated the Prevention and Cure Guidelines of Chronic Hepatitis B(CHB), so as to provide standard guidance to CHB treatment based on the latest clinical evidence. Traditional Chinese Medicine (TCM) has inherent advantage in China’s medical care, however, none of the new guidelines evaluated the efficacy of TCM treatment (or any other complementary therapies) for CHB. In this article, the potential advantages and applications of TCM treatment for CHB were discussed by comparing views of the guidelines in the aspects of treating goals, clinical end points, target populations and discontinuation time etc.