丹参类静脉制剂对择期PCI围手术期心肌损伤的保护作用研究
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国家自然科学基金项目(编号:81273741);国家中医药管理局重点学科基金;北京市215人才基金;北京市十百千人才基金


Observation of Salvia Miltiorrhiza Intravenous Agents on Selective PCI Perioperative Myocardial Injury
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    摘要:

    目的:观察丹参类静脉制剂对择期PCI围手术期心肌损伤的保护作用。方法:非同期对照观察常规治疗及加用丹参粉针、丹参酮ⅡA注射液、丹红注射液,对择期PCI的不稳定心绞痛(Unstable Angina,UA)患者血清心肌标志物肌酸激酶同工酶(Myocardial-bound Creatine Kinase,CK-MB)的影响,探讨丹参类制剂对择期PCI围手术期的心肌保护作用。结果:PCI术后与术前相比较,常规组术后血清中CK-MB水平升高,差异有统计学意义(P<0.05);丹粉组术后血清中CK-MB水平较术前亦有升高,差异无统计学意义(P>0.05);丹酮组术后血清中CK-MB水平较术前有所降低,其差异接近统计学意义(P=0.053);丹红组术后血清中CK-MB水平较术前有所降低,差异有统计学意义(P=0.033)。结论:丹参类静脉制剂对择期PCI围手术期心肌损伤的具有一定的保护作用,以丹红注射液作用最为明确。

    Abstract:

    To observe the effect of salvia miltiorrhiza intravenous preparations on selective PCI perioperative myocardial injury. Methods: To observe the effect of routine treatment combined with salvia miltiorrhiza powder injection, tanshinoneⅡA injection, Danhong injection respectively on serum myocardial markers Myocardial-bound Creatine Kinase(CK-MB) in the serum of patients with unstable Angina(UA) after selective PCI. Then discuss its protective mechanism on perioperative myocardium. Results: Compared with before treatment, the CK-MB level in the routine treatment group had increased with statistically difference(P<0.05). CK-MB level in the salvia miltiorrhiza group also increased with no statistical difference(P>0.05). CK-MB level in Tanshinone group decreased(P=0.053), and that of Danhong group also decreased(P=0.033). Conclusion: Salvia miltiorrhiza intravenous preparation, especially Danhong injection, has certain effect on PCI perioperative myocardial injury.

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周琦,张大炜,刘红旭,张竹华,李爱勇,林晓烁,田伟,李腾飞,邢文龙.丹参类静脉制剂对择期PCI围手术期心肌损伤的保护作用研究[J].世界中医药,2016,(03).

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  • 收稿日期:2016-02-24
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  • 在线发布日期: 2016-03-14
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