A 10-year RCT(Random control trials) that followed CHD(Coronary Heart Disease) patients who took Yiqi Liangxue Shengji Recipe (YL) after PCI was conducted in order to observe the quality of life and clinical long-term effect of YL. Methods: Ninety-seven cases were randomly divided into YL treatment group(n=56) and control group(n=46) on the basis of our previous research. Patients’ quality of life were observed during10 years. Results: YL treatment group had better quality of life in 6 month after PCI(P<0.05), and it also had better long-term effect without statistical difference(P>0.05). The incidence of adverse effects in the two groups had significant difference(P<0.05). YL intervention and regular treatment come into logistic regression( P<0.05), showing that the two aspects had protective effect on patients’ quality of life. Conclusion: Taking YL has positive effect on patients’ health, and YL recipe can improve the long term quality of PCI patients’ life. Besides, it has long-term clinical efficacy.