To observe the curative effect of jianpiqingwei therapeutic in treating overweight women with insulin-resistant and polycystic ovary syndrome.Methods:Select 52 women of BMI>23with IR and PCOS while spleen deficient and stomach heat and modified Banxiaxiexin Decoction were taken twice a day for 12weeks.The oral glucose tolerance test and insulin release test were performed and the area under glucose and insulin curve were measure before and after 12 weeks’ treatment，as well as hormone levels (E2,FSH,LH,T)，CHO，TG，LDL-C，HDL-C.The rate of pregnancy and double phase of BBT were counted after 4 weeks，8 weeks，12 weeks’ treatment.The menstrual cycle score，height，weight，waist circumference，hip circumference，BMI，WHR were recorded before and after 4 weeks，8 weeks，12 weeks’ treatment.Results:1) Compared with before-treatment,area under insulin curve，2 hour post-meal insulin and TG were significantly lower after 12 weeks’ treatment (P<0.05).2) There was no significant difference in E2、FSH、LH、LH/FSH、T after 12 weeks’ treatment.3) After 12 weeks’ treatment，the cumulative rate of pregnancy was 18.2% and double phase of BBT was 53.1%.4) The menstrual cycle score was significantly lower after 4 weeks’ treatment，8 weeks’ treatment，12 weeks’ treatment compared with before-treatment(P<0.05；P<0.01).5) Compared with before-treatment，the waist circumference was significantly reduced than after 4 weeks’ treatment，8 weeks’ treatment，12 weeks’ treatment，while BMI and WHR had no significant changes.Conclusion:Jianpiqingwei therapeutic can improve insulin sensitivity in overweight women with insulin-resistant and polycystic ovary syndrome and lower triglyceride.Also it can promote spontaneous ovulation and autonomous menses recovery.