To observe the clinical efficacy and safety of warm and circulate therapy in treating superficial thrombophlebitis of lower extremity. Methods:Eighty patients with superficial thrombophlebitis of lower extremity were randomly divided into treatment group (Jiusheng decoction) and control group (Huoxue Tongmai decoction) in Ulcerous Vascular Surgical Department from January 2012 to January 2014. The changes of curative effect, clinical symptoms, signs, and Doppler ultrasound were observed. Results:The cure rates were 76.36% and 51.35% in treatment group and control group respectively. Compared with pre-treatment, the clinical symptoms, signs, and the results of Doppler ultrasound in two groups were significantly improved (P<0.05), and these results in treatment group were significantly improved compared with control group (P<0.05). Conclusion:Compared with disperse blood stagnation and dredge collateral method, warm and circulate therapy for treating superficial thrombophlebitis of lower extremity has a higher cure rate and a lower recurrence rate, and can provide significant efficacy in reducing the level of inflammation, relieving pain, decreasing the size of scleroma and healing hyperpigmentation. This treatment was feasible and safe.