To study the effect of Yunnan Baiyao Powder joint hemostasia packing is used to endoscopic minimally invasive surgery.Methods:160 patients with nasal endoscopic minimally invasive surgery were selected in our hospital from January to December in 2015.They were divided in two groups with the random number table method，each group had 80 cases，the control group were treated with medical PVA sponge nasal packing，the experimental group used Yunnan Baiyao Powder daube wound on the basis of the control group.Compared two groups of the total effective rate，the degree of pain，the degree of nasal mucosal swelling and adverse reaction.Results:The total effective rate of the experimental group was 88.75%，and the total effective rate of the control group was 80%，the difference had statistical significance(P<0.05).The number of patients with normal and mild pain in the experimental group than in the control group，the number of moderate and severe pain was less than the control group，the difference had statistical significance(P<0.05).The number of mild swelling of nasal mucosa in experimental group was more than that in control group，the number of moderate and severe nasal mucosal swelling was less than that of control group，and the difference had statistical significance(P<0.05).Patients in the experimental group were headache，nasal distending pain，hematoma of nasal septum and middle turbinate adhesion，complication incidence was significantly lower than that in the control group，and the difference had statistical significance(P<0.05).Conclusion:Yunnan Baiyao Powder joint hemostasia packing is used to endoscopic minimally invasive surgery smear tamponade can obviously reduce the patient’s blood loss，alleviate pain degree and nasal mucosa swelling degree，less adverse reaction.