To explore the clinical effects of integrated Chinese and western medicine in treating children with hand, foot, and mouth disease. Methods:Total 120 cases of children with hand, foot, and mouth disease during January 2009 to December 2012 in Meizhou City People’s Hospital were included in the clinical studies, and randomly divided into two groups. The control group were given routine western medicine treatment, while the treatment group were given integrated Chinese and western medicine treatment. The therapeutic effects of two groups were analyzed. Results:The overall effective rate of the treatment group (95.0%) was significantly higher than that of the control group (80.0%) (P<0.05). The satisfactory degree of parents of the treatment group (96.7%) is significantly higher than that of control the group (75.0%). Fever duration and herpes subsided time of the treatment group were (1.87 ± 0.65) d, (2.28 ± 0.52) d respectively, significantly less than the control group (2.45 ± 0.92) d, (3.34 ± 0.64) d, (P<0.05). Conclusion:Integrated Chinese and western medicine is effective in treating children with hand, foot, and mouth disease and can relieve fever and herpes, which has significant clinical value.