To observe the effect of Wenxin granules on Cys-c serum and Hcy levels in patients with coronary artery disease and lipid disorders and the clinical efficacy of Wenxin granule. Methods: To select 120 patients enrolled ino our hospital from October 2013 to October 2014, then randomly divided them into two groups: the observation group (n=60) and the control group (n=58). Patients in the control group were treated with conventional western medicine and the observation group were treated with Wenxin granules on the basis of conventional western medicine, 9 g/a time, taken with water, 3 times/d. Both groups were treated for 2 courses, each course 4 weeks. Before and after treatment, changes in serum Cys-c, Hcy levels and the degree of coronary stenosis were compared. Results: After two courses of treatment, the total efficiency in the observation group(93.33%) was significantly higher than that of the control group(81.67%), and the difference was statistically significant(P<0.05). Besides, serum Cys-c and Hcy levels of two groups both declined, while the observation group decreased more significantly, and the difference was statistically significant (P<0.05). In addition, coronary stenosis in the two groups also improved(P<0.05), and the observation group performed better than the control group(P<0.05). No significant adverse reactions have been seen. Conclusion: Wenxin granule has obvious efficacy in treating coronary artery disease. It can improve the patient’s coronary artery stenosis situation, lower serum Cys-c and Hcy levels, has high clinical efficacy and low incidence of adverse reactions. It is worthy of clinical application.