To investigate the effect of Jiangtang Xiaoke granule(JTXKG)combined with metformin on the blood glucose and blood lipids in type 2 diabetic mice.Methods:ICR mice were fed by high-fat-diet for 4 weeks，combined with intraperitoneal injection of streptozocin in 100mg·kg-1.The mice were randomly divided into normal group，model group，western medicine group(metformin)and combination groups(JTXKG，combined with metformin，in low，medium，and high dose).After 4-week treatment，the body weight，fasting blood glucose(FBG)，fasting serum insulin(INS)，glucagon，and blood lipid(BL)were tested，and the glucose tolerance was measured.Results:Compared with model group，combination groups lost body weight(P<0.05)，decreased FBG(P<0.01)，INS(P<0.05)and glucagon(P<0.05)，improved glucose tolerance(P<0.05)，and showed certain BL changes.Compared with western medicine group，combination groups FBG were lower(P<0.05).Conclusion:JTXKG combined with metformin showed glucose and lipid metabolism improvement，and was more effective in weight loss and blood glucose reduction than metformin alone.