This research aims to investigate the mechanism of Huishen Granule alleviating intracerebral inflammatory response in rats with traumatic injury injury(TBI). Methods:Using the equipment of fluid percussion injury (FPI) to establish moderate FPI model in SD rats.The traumatic pressure was (170±10)kPa, traumatic time was (20±2)ms. Randomly divided rats into 6 groups: normal group, sham group, model 3 day group, model 7 day group, experimental 3 day group, experimental 7 day group. Experimental 3 day group and experimental 7 day group were given 2 mL fluid(contain 0.27 g Huishen Granule) into rats’ stomach instantly after trauma, and then given 2 mL fluid in the morning and at night. Using real-time polymerization chain reaction(RT-PCR) to examine the change of ICAM-1 in all 6 groups. Results:Compared with normal group, the ICAM-1 of model 3 day group, model 7 day group and experimental 3 day group increased obviously(P<0.01). However, compared with model 3 day group, the ICAM-1 of experimental 3 day group descended significantly(P<0.05). Compared with model 7 day group, the ICAM-1 of experimental 7 day group declined obviously(P<0.05). Conclusion:The mechanism of Huishen Granule alleviating intracerebral inflammatory response was through prohibiting the expression of ICAM-1 and avoid aggravation of TBI.