To observe the clinical effect of integrated Chinese and western medicine in the treatment of 76 cases of children patients with cough variant asthma.Methods:During Jan. 2012 to Dec. 2012, there were 76 cases of children patients diagnosed as cough variant asthma in our hospital. Though treated repeatedly with multiple drugs including antibiotics, phlegm reducing medicine, it was invalid. During hospitalization they were given the integrated Chinese and western medicine treatment: ZhiKeLing oral liquid, 3 times a day, 1 bottle each time; Ketotifen tablets, 0.5 mg each time, once a day; Montelukast Sodium Chewable Tablets, 1 piece each time, once a day. Ambroxol Hydrochloride Liquid, 2.5 ~ 10 mg each time, twice a day. They were also given Azithromycin Granules for 5d, each dose of 12 mg/kg once a day if necessary. The cough symptom and symptom integral ameliorative after two weeks’ treatment were observed.Results:After treatment, the symptom integral ameliorative during daytime and night were both improved significantly than before (P<0.05). The average relieving duration of cough was (14.5±2.6) d. The total clinical effective rate was 92.1%. All children patients showed no serious adverse reactions during the treatment. Conclusions: The integrated Chinese and western medicine in treatment of children patients with cough variant asthma has a function of the effect of synergy, the effect of clinical treatment is satisfying, safe and effective.