To observe Zishenqingqi Granule’s influence on bone transformation indexes and calcium phosphorus induced by metabolism systemic lupus erythematosus (SLE) after using glucocorticoid and to discuss its effect on bone metabolic abnormalities induced by glucocorticoids.Methods:72 cases of SLE-DAI between 5-14 points with application of glucocorticoids were randomly divided into the treatment group and the control group (n=36) for 12-week treatment. Alkaline phosphatase (ALP), osteocalcin (OG), type I collagen peptide (b-CTX) C-end and serum calcium (BCa), serum phosphorus (BP) and the changes of TCM symptoms were observed before and after treatment.Results:after 12-week treatment, type I collagen peptide C-end of the control group after treatment was higher than that before the treatment but with no significant difference. Osteocalcin level of the treatment group was obviously higher after the treatment and increased obviously compared with control group. Alkaline phosphatase level in the treatment group has obvious difference compared with the control group. Blood calcium of the control group significantly lower after the treatment, and blood calcium and blood phosphorus levels of the treatment group after treatment were significantly higher than those of the control group. TCM symptoms in the treatment group significantly improved and symptoms, like lower back pain and facial blushing released better compared with those of the control group. symptoms, like five-center heat, insomnia and much dream also have improved significantly.Conclusion:There is no obvious effects of Zishenqingqi Granule on bone resorption, but may control the inhibition function of glucocorticoid on bone formation and increase serum calcium phosphate levels by adjusting the blood calcium phosphorus absorption.