To study the influence of moxibustion and moxa smoke on serum VCAM-1, ICAM-1 and MCP-1 levels of ApoE knockout mice, so as to investigate the potential mechanism of moxibustion treating atherosclerosis.Methods:Atherosclerosis model was established by ApoE gene knock-out mice with high-fat diet feeding. The mice were randomly divided into the model group, moxibustion group, moxa smoke group and cigarette smoke group. After 12 weeks interference, the levels of VCAM-1, ICAM-1 and MCP-1 in the mice serum were measured.Results:Compared with the model group, the serum VCAM-1, ICAM-1 and MCP-1 levels of moxibustion group and moxa smoke group were decreased significantly（P<0.05). There is no significant difference between the moxibustion group and moxa smoke group. No significant difference was observed between cigarette smoke group and model group.Conclusion:Moxibustion and moxa smoke may obviously reduce serum VCAM-1, ICAM-1 and MCP-1 levels in atherosclerosis mice.