To investigate the clinical efficacy of treating diabetic peripheral neuropathy by point injection with Salvia Root injection. Methods: Diabetic peripheral neuropathy patients of 60 cases were randomly divided into four group: control group, acupuncture group, point injection Group A, point injection Group B, each group has 15 cases. Patients of control group were treated with ear beans on no specific points, patients of acupuncture group by acupuncture. Patients of point injection Group A were treated with point injection with physiological saline, patients of point injection Group B with point injection with Salvia Root injection. The changes of TCSS (Torontoclinical scorins system) scores, motor and sensory nerve conduction velocity (MCV and SCV) of bilateral median nerve and common peroneal nerve after 14 days were analyzed. Results: The total effective rate of point injection Group B (93.34％) was significantly different compared with the other groups (P<0.05). Except for the control group, TCSS scores, MCV and SCV of bilateral median nerve and common peroneal nerve of other three groups were all improved and point injection Group B were improved more than the other two groups (P<0.05). Conclusion: Point injection with Salvia Root injection has clear effect on diabetic peripheral neuropathy.