To study the effect of warming needle moxibustion combined with acupoint injection with Cervus and Cucumis Polypeptide (CCP) on rheumatoid arthritis serum rheumatoid factor (rheumatoid, factor, RF) and synovial membrane of bone morphogenetic protein (BMPs) effect, and to explore its therapeutic mechanism. Methods: According to the hospital admission date, total 214 cases of rheumatoid arthritis patients from January 2014 to March 2015 in Department of Endocrinology were randomly divided into control group and treatment group, with 107 cases in each group. The control group was treated with oral leflunomide as well as warming needle moxibustion on some sore acupoints and CV 4, ST 36, BL 2O, CV 6, GB 34, BL 23, BL18 etc. for 20 minutes every time. The control group was also treated with CCP acupoint injection on the basis of control group’s treatment; two groups were treated for three courses. Pathological examination of patients’ MMP-1 and BMPs, erythrocyte sedimentation rate (ESR), serum rheumatoid factor IgA-RF, IgM-RF-, as well as joint pain, swelling, tenderness, dysfunction index, duration of morning stiffness, grip strength and total effective rate were recorded and analyzed before and after the treatment. Results: Warming needle moxibustion combined with CCP acupoint injection improved BMPs, reduced MMP-1, ESR, IgA-RF, IgM-RF, shortened the duration of morning stiffness, relieved the clinical symptoms, treatment group compared with control (P<0.05), the difference was statistically significant. Conclusion: The therapeutic effect of warming needle moxibustion combined with CCP acupoint injection in treatment of rheumatoid arthritis is significant, and it may function through acupuncture and moxibustion to stimulate qi and blood movement, dredge channels and activate col laterals, promote the local blood circulation and local tissue. CCP injection can also lead to the generation of BMPs synthesis, and inhibition of allergic allergic reaction caused by RF.