“The lung governing regulation of water passages ” has been adopted in the diagnosis and treatment of diseases. The author summarizes the expression of “ the lung governing regulation of water passages ” on Febrile Diseases and Synopsis of Golden Chamber, combining with the comments of practitioners in later generations as well as the application in modern clinical practice. Moreover, the relation between the lung and water metabolism is discussed. The purpose is to provide strategies for water metabolic diseases under the perspective of traditional Chinese medicine treatment.