As a part of biology systems, metabonomics is an emerging subject. However, with some in-depth study of metabonomics carried out in traditional Chinese medicine, it was found that the subject has some similarity with traditional Chinese medicine, such as thinking mode as well as the nature of integrity, dynamics and instantaneity, which will provide powerful research methods for TCM syndrome’s objectification and standardization. According to the research results from some literature and research groups, research hypothesis of metabonomics in the traditional Chinese medical symptoms of HIV/AIDS is proposed.