To observe the clinical effect of Warming Dredging Dissipating Mass Method in the treatment of hyperplastic nodular goiter. Methods: Total 95 cases of hyperplastic nodular goiter were randomized into two groups. The treatment group with 55 patients were treated with levothyroxine tablet and Warming-Dredging prescription and Xiaojin capsule and the 40 cases in control group with levothyroxine tablet. The efficacy was observed after three months in both of the two groups. Results: The thyroid volume and thyroid nodule size and the arterial blood flow signal of nodules of the two groups were controlled, the differences were statistically significant (P<0.05). Conclusion:Warming Dredging Dissipating Mass Method is effective in the treatment of hyperplastic nodular goiter.