To observe the effect of Chinese medicine’s Reinforcing Healthy Qi and Eliminating Pathogen Method on hemodynamics of patients with septic shock and to explore its mechanism. Methods: Total 78 patients with septic shock were randomly divided into control group (37 cases) and Chinese medicine intervention group (41 cases). The control group’s patients were treated with sepsis bundles therapy according to the treatment guidelines and Chinese medicine intervention group with Shenqi Fuzheng Injection Combined with Xuebijing Injection by intravenous drip on the basis of the control group’s treatment. The serum lactic acid (LAC), cardiac index (CI) and extravascular lung water content index (EVLWI), reduced vascular drug use time of the two groups, acute physiology and chronic health score (APACHE II score), length of stay in the ICU and 28-day mortality were recorded before and after the treatment. Results: The levels of Lac of the two groups dropped after the treatment, and the result of Chinese medicine group was more significant (P<0.05). CI of the two groups rise after the treatment, the improvement of Chinese medicine intervention group was significantly higher than that of the control group (P<0.05). EVLWI and ITBVI of Chinese medicine intervention group had significant improvement, while the control group had no obvious effect, the differences were statistically significant (P<0.05). The use of reduced blood vessel drugs, live ICU time of Chinese medicine were shorter than the control group, with significant statistical differences (P<0.05). APACHEII scores of the two groups decreased after treatment, but the Chinese medicine intervention group decreased more significantly (P<0.05). There was no significant difference in mortality rate between the two groups (P>0.05). Conclusion: Chinese medicine’s Reinforcing Healthy Qi and Eliminating Pathogen Method can improve the pus toxic shock hemodynamics and relieve patients’ symptoms, so as to shorten the time of ICU stay.