To provide reasonable clinical treatment with good curative effects for gastrointestinal adverse reactions after HAART treatment. Methods:According to the inclusive criteria, a total of 36 patients with HAART gastrointestinal post-treatment adverse reactions were included and randomly divided into the treatment group (20 cases) with Xiangsha Liujunzi Granule once a day for 14 days and the control group (16 cases) with conventional western medicine treatment. Symptoms integrals of the two groups before and after medication were recorded and curative effects between the two groups were compared. Results:Patient’s age and symptoms integral of the two groups before and after treatment showed no statistical difference poor appetite, nausea and vomiting caused by HAART can be relieved. The effective rate of treatment group was (87.6±3.3)% on average, higher than that of the control group (76.8±10.1%) (P<0.05), which showed significant statistically difference. Conclusion:Xiangsha liujunzi Granule may reduce the gastrointestinal reaction caused by HAART treatment.