To evaluate the clinical effects of cooling blood and removing blood toxin method in treating chronic severe hepatitis B patients with the type of heat-dampness, stasis and toxin.Methods:A hundred patients with severe hepatitis B were treated with cooling blood and removing blood toxin method.Results:Patients with symptoms and signs improved after treatment. There was no significant difference in blood routine test results, electrolytes, renal function, albumin (ALB), interleukin-2 (IL-2) (P>0.05). ALT, AST, DBiL, TBiL, GGT, NH3, hs-CRP, TNF-α, IL-8 were decreased compared with those before the treatment with statistically significance (P<0.01;P<0.05), while PTA and IL-10 were increased compared with those before the treatment (P<0.05) without any significant difference (P>0.05).The total effective rate was 55.0%.Conclusion:Cooling blood and removing blood toxin method in treating chronic severe hepatitis B may be safe and effective, close monitoring for laboratory indicators may help the diagnosis and treatment of severe hepatitis B.