To study the clinical effect of the treatment of the rheumatoid arthritis (RA)and secondary osteoporosis(OP) with kidney-tonifying and collaterals-dredging medicinals combined with western medicine. Methods: Total 72 cases in the hospital from January 2013 to January 2015 during the hospitalization for rheumatoid arthritis with secondary osteoporosis were randomly divided into two groups: study group and control group. Study group was treated with kidney-tonifying and collaterals-dredging medicinals with salmon calcitonin injection every day as well as oral D2 calcium hydrogen phosphate for two months. The control group only received salmon calcitonin injection and dimension D2 calcium hydrogen phosphate, also for two months. Clinical therapeutic effects, the improvement of clinical symptoms and the bone metabolism of two groups were compared before and after treatment. Results: The total effective rate of study group was 94.5%, better than the control group’s 69.5%, the difference of the two group was significant (P<0.01). The calcium ions, erythrocyte sedimentation rate (ESR) and bone mineral density(BMD) results of the two groups had no statistical significance compared with before the treatment (P>0.05). After the treatment, the ESR declined obviously, calcium and bone mineral density rose significantly (P<0.01). The situation of morning stiffness, joint tenderness, joint swelling and joint function of the both group had no statistical differences compared with before the treatment (P>0.05). After the treatment, duration of morning stiffness, joint tenderness, joint swelling and joint function of the study group were significantly improved, and the results were superior to the control group significantly (P<0.01). Conclusion: Kidney-tonifying and collaterals-dredging medicinals combined with western medicine has significant clinical effect in the treatment of rheumatoid arthritis and secondary osteoporosis. It can effectively relieve the patient’s clinical symptoms, alleviate bone loss, regulate bone metabolism and relieve osteoporosis.