To observe the effect of Lotus dragon eliminating tumor prescription on improving living quality of patients with middle-late primary liver cancer(PLC),discuss the effect mechanism of traditional Chinese medicine(TCM) treatment of liver cancer,and explore the most effective treatment method of liver cancer.Methods: Using open and comparative trial,middle-late PLC,were randomly divided into three groups,namely Lotus dragon eliminating tumor prescription group(40cases), lotus dragon eliminating tumor prescription combined elemiene and chemotherapy drugs intervention group (40cases),Singly western medicine chemotherapy drugs intervention group (40cases).A treatment course of thirty days was count as an observation period.The TCM syndrome integral and AFP value change of three groups before and after treatment were observed and analyzed statistically, as well as liver function, Physical status(KPS) score,Tumor patients’ quality of life QOL score.Results: In the improvement of traditional Chinese medicine syndrome、the comparison of KPS score and the comparison of QOL score , the effective rate of Comprehensive treatment group and the TCM group were superior to the chemotherapy interventional group,the difference has statistical significance(P<0.05); The effective rate of Comprehensive treatment group to reduce the AFP was superior to the TCM group and chemotherapy interventional group, the difference has statistical significance(P<0.05).Conclusion: Lotus dragon eliminating tumor prescription can ease the clinical symptoms of middle-late stage primary liver cancer patients, AST and ALT value, enhance physical fitness and improve the quality of life.