To observe the clinical effect of traditional Chinese medicine combined with NB-UVB in the treatment of vitiligo. Methods:A hundred patients with vitiligo who received treatment from December to February 2014 were randomly divided into observation group and control group with 50 patients in each group. Patients in the control group treated with traditional Chinese medicine treatment, and patients in the observation group were additionally treated in combination of NB-UVB. The total repigmentation rate efficiency and side effects of the two groups after the treatment were compared. Results:Vitiligo of both the two group after the treatment was improved. Repigmentation rate of patients in the observation group was higher than that of control group with statistical significance difference (P<0.05). The total efficiency of the observation group (76.1%) was higher than that of the control group (47.1%), which showed statistically significance difference (P<0.05). The occurrence rate of adverse reactions of the two groups showed no statistically significant difference (P>0.05). Conclusion:Traditional Chinese medicine combined with narrow spectrum UVB phototherapy in the treatment of vitiligo is significant and patients’ symptoms were improved significantly with less adverse reactions, which is worth of clinical use.