To observe the clinical effect of Runzao Zhiyang decoction on reliving itching and its correlation with curative effect.Besides,to explore the evaluation mode of syndrome and symptom combination.Methods:According to 1：1 criteria,240 cases were collected as the subjects.Using stratified random,positive drug parallel control,double blind double simulation,evaluate the antipruritic effect and symptom relief effect of Runzao Zhiyang decoction and the correlation of main symptoms and syndrome by observing the main symptom of skin pruritus of yin deficiency and wind dryness syndrome.Results:1) The total efficiency rate of Runzao Zhiyang decoction is 55.93%,and total effective rate is 92.37%.The effect is more evident that of the control drug (P<0.05).The total efficiency rate of Runzao Zhiyang decoction in treating yin deficiency and wind dryness syndrome is 67.80%,and total effective rate is 98.31%.While there are no statistical significance (P>0.05) between the decoction and the control drug.2) There are obvious correlations among the curative effect,symptom relief effect and TCM scores before and after the treatment,with P<0.05.The major symptoms itching increased at night and skin prutitus have obvious correlations to itching scores (P<0.05).Besides,there are clear correlation between syndrome and symptom scores of patients of yin deficiency and wind dryness syndrome while none in atypical syndrome patients (P<0.05).Conclusion:Runzao Zhiyang decoction has a good antipruritic effect on skin pruritus with yin deficiency and wind dryness syndrome.It can improve itching,increase itching in the night and skin dryness.The typicality of clinical syndrome is the influential factor of its curative effect.In addition,combination of symptom and syndrome evaluation mode is suitable in researching Chinese medicine’s effect and its characteristics.