To discuss the apoptotic effect of Clerodendron bungei flavornoids on liver tumor cells and the possible mechanism.Methods:To culture HepG2 cells in virto,and investigate the apototic effect of clerodendron bungei flavornoidson by flow cytometry.The mRNA expression levels of proteins β-catenin,Tcf-4 and CD44v6 of HepG2 tumor cells were detected by RT-PCR after 48h treatment of flavornoids.Results:Flow cytometry indicates that along with the rising dose of Clerodendron bungei flavornoids,the apoptosis rate of HepG2 cancer cells begin to grow.After 48h treatment of flavornoids,the mRNA expression levels of proteins β-catenin,Tcf-4 and CD44v6 of HepG2 tumor cells were down-regulated significantly,and compared with the control group,significant difference exist.Conclusion:Clerodendron bungei flavornoids can induce the apoptosis of HepG2 tumor cells and decrease the mRNA expression levels of proteins β-catenin,Tcf-4 and CD44v6.This might relate to its regulating effect on Wnt/β-catenin pathway and inhibit the key gene’s expression.