To observe the clinical prevention and intervention effect of Shenqi decoction on coronary restenosis of patients with coronary heart disease after PCI.Methods:A total of 218 patients with coronary heart disease treated in this hospital were divided into the research group and control one according to the random number table,with 109 cases in each group.Patients in the control group were given the routine western medicine therapy; while patients in the research group were given the treatment of Shenqi decoction in addition to the routine western medicine therapy.The changes of TCM syndrome scores and changes of inflammatory markers before and after the treatment and incidence of coronary restenosis were compared between two groups.Results:The magnitude of decrease in qi deficiency symptom score and blood stasis syndrome score of patients at 3 months and 6 months after taking the medicine in the research group were significantly better than those in the control group (P<0.05).The levels of high-sensitivity C-reactive protein,activated T lymphocytes and soluble interleukin-2 receptor at 3 months and 6 months after the treatment the treatment in the research group were significantly better than those in the control group (P<0.05).The incidence of restenosis for patients in the research group was 17.43%,which was significantly lower than 34.86% of control group (P<0.05).Conclusion:The application of Shenqi decoction in the coronary heart disease after PCI can significantly improve the TCM syndrome scores of patients,inhibit the chronic inflammatory state,enhance the immunity levels and reduce the risk of coronary restenosis.