To observe the clinical efficacy of modified Minor Bupleurum Decoction combined Bamboo Leaf and Gypsum Decoction to treat cold-induced refractory fever. Methods: Patients of 58 cases were randomly divided into two groups (29 cases in each group). In treatment group, modified Minor Bupleurum Decoction combined Bamboo Leaf and Gypsum Decoction was administered 30 min after the meal strictly in accordance with the principle of “frequent administration at small amount.” Moreover, the patients lived a life in strict observation of light diet, avoiding heavy foods, greasy foods and bathing etc. As for the control group, primary disease treatment to restrict virus and infection and the treatment to rectify the water electrolyte and acid-base balance disorders were administered. Results: The treatment group’s curative effect was significantly higher than the control group. Conclusion: The modified Minor Bupleurum Decoction combined Bamboo Leaf and Gypsum Decoction is clearly effective for the cold-induced refractory fever.