To observe the effect of Sichuan Lovage Rhizome and Red Peony Root on angiogenin-1 (Ang-1),ischemia induced factor-1 a (HIF-1 a) on rats with cerebral ischemia-reperfusion.Methods:The model of rat with middle cerebral artery ischemia-reperfusion was established with suture-occluded method.SD rats were randomly divided into control group,model group and Sichuan Lovage Rhizome and Red Peony Root low and high dose groups,Ginkgo group.Ang-1 in rat serum was tested with ELISA method.HIF-1a mRNA expression in ischemia brain tissue was detected with real-time fluorescent quantitative polymerase chain reaction (rt-PCR).Results:Ang-1 in rat serum in model groups increased on days 3,7 and 14 compared with the control group (P<0.05).HIF-1a expression with Rt-PCR increased in model groups on day 3,7 and 14 compared with control group (P<0.05).HIF-1a expression in model group on day 3,7 and 14 was lower than Sichuan Lovage Rhizome and Red Peony Root low and high dose groups,Ginkgo group (P<0.05).Conclusion:Sichuan Lovage Rhizome and Red Peony Root could enhance Ang-1 in rats with cerebral ischemia-reperfusion and HIF-1a mRNA expression in ischemic brain tissue,suggesting that the mechanism of Sichuan Lovage Rhizome and Red Peony Root on treating cerebral ischemia may be related with promoting angiogenesis.