To investigate the effect of Fuzheng Xiaoai I decoction on VEGF expression of mice with liver metastasis of colon cancer, and discuss its possible mechanism.Methods:The tumor models were established by injecting human carcinoma of CT26 cells under the balbc mice. Balbc mice with liver cancer cells are randomized divided into 4 groups (12 in each group): 1）Control group; 2）5-Fu group; 3）Fuzheng Xiaoai I group; 4）Fuzheng xiaoai I+5-Fu group. The life quality of mice, tumor inhibiting rates, and the expression of VEGF in tumor tissue were measured.Results:The life quality of group 4 and 3 are better than that of the other groups. Besides, the tumor size of group 4 was the smallest, and that of the control group was the biggest. The levels of VEGF in all groups were decreased.Conclusion:Fuzheng Xiaoai I could inhibit the angiogenesis of tumor possibly by down regulating VEGF and obstructing the formation of tumor vessels.