To study the ultrasonic extraction process of total flavonoids in Xuelian Shiwei tablet.Methods:Taking the total content of flavonoids as the detect index,and the orthogonal experiment design was adopted to investigate the best route for extracting the total flavonoids from Xuelian Shiwei tablets.Taking rutin as reference,and ultraviolet spectrophotometry was applied to determine the content of flavornoids.Results:The best method of extraction is 75% ethanol as solvent,at 55 ℃,for 50 mins under ultrasonic.The average extraction volume was 1.287 mg/g.Conclusion:This method is easy to operate,and can enhance the extraction rate in a large deal.