This paper aims to investigate the TCM intervention in the imbalance of neurovascular unit (NVU) homeostasis in depression patients.Through the analysis of the pathogenesis of homeostasis changes of the NVU in depression and combination of TCM theory and modern medical researches,this paper proposed the general intervention ideas:simultaneous treatment of qi and blood,simultaneous consideration of both nerves and blood vessels and benefiting the original qi and relieving stagnation then target to the NVU.Focused on the key links of the NVU homeostasis changes in depression,this paper suggested to tonify qi and reduce phlegm to treat depression,adjust the blood brain barrier to maintain the NVU micro-environment,reinforce the vital essence and activate blood to treat depression,build the neural vascular coupling to reconstruct NVU basic structure,consolidate the constitution and detoxicate to relieve depression,resist nerve inflammation to protect the NVU components.In conclusion,the target to the NVU should sufficiently manifest the principle of the holistic and differential treatment of TCM.