N-methyl-D-aspartate receptor (NMDAR) has a variety of different subsets that are located differently on the central nerve.It involves in the transmission of signals in the body and regulates the excitability of neurons,such as mediating development of somatic and visceral pain.The NR2B subset of NMDAR is mostly common researched in its pain-related mechanism.Also,visceral pain is a common clinical symptom,which was induced by mechanical and chemical stimulation to the sensory nerve endings of the organs and chest and abdominal walls or local ischemia,smooth muscle spasm and retained metabolite.Electric acupuncture was proved to have significant effect in the treatment of visceral pain and studies found that electric acupuncture can regulate NMDA receptors,especially NR2B subset,revealing a potential analgesia target of electric acupuncture.This article analyzed the structure,function,and mechanism of NR2B subset and discussed its mechanism in reliving chronic visceral pain on the basis of the TCM (traditional Chinese medicine) researches in this field in recent years.