To observe the effects of Huachansu capsule combined with chemotherapy in the treatment of advanced gastric cancer, as well as its effect on patients′ life quality and its adverse reaction.Methods:Sixty cases meeting the inclusion criteria were randomly divided into the treatment group and control group. The control group was treated by FOLFOX4 regimen chemotherapy and supportive treatment, and the treatment group by those plus Huachansu capsule. Short-term objective efficiency, stable rate, quality of life and adverse reaction were compared between the two groups.Results:After treatment, short-term objective effective rate of the treatment group was significantly higher than that of the control group (P<0.05). The quality of life and adverse reaction index of the treatment group were obviously superior to that of the control group (P<0.05).Conclusion:Both Huachansu capsule combined with chemotherapy and the single chemotherapy therapy have curative effects in treating advanced gastric cancer. However, Huachansu capsule combined with chemotherapy could better improve patients′ quality of life, and reduce adverse reaction of chemotherapy.