To observe the clinical efficacy of Beimu Exiao pills in treating Nodular Goiter(NG) of blood stasis and phlegm stagnation type. Methods: A total of 60 patients were randomly divided into traditional Chinese medicine group (taking Beimu Xiaoer pills) and euthyrox group (taking euthyrox). Treatment course lasts for 12 weeks. Record TCM symptom scores before and after treatment of the two groups, then compared the clinical efficacy of the two medication. Results: After treatment, patients in both groups showed lower TCM scores, while TCM group performed better than euthyrox group(P<0.05). Besides, the clinical efficacy of traditional Chinese medicine TCM group was higher than euthyrox group (P<0.05). There are no adverse reactions in both groups, however, TSH levels in euthyrox group is lower than before(P<0.05) while no significant difference showed in treatment group(P>0.05). Conclusion: Beimu Exiao pills can significantly reduce TCM scores in NG patients of blood stasis and phlegm stagnation type. Besides, it can relieve TCM symptoms and has good clinical efficacy and safety.