To observe the clinical curative effect of Honghua Ruyi Pill on chronic pelvic inflammatory disease, and to analysis its possible mechanism.Methods:A hundred patients with chronic pelvic inflammatory disease treated in our hospital were randomly divided into the routine treatment group and the observation group with 50 cases in each group. The routine treatment group received conventional antibiotic therapy, while Honghua Ruyi Pill was added for the observation group with the same therapy of routine treatment group. Both of the two groups were treated for 4 weeks and the changes of self-evaluation rating scale on pelvic inflammatory disease, and the concentration changes of cervical mucus TNF-α/IL – 2 were compared between the two groups before and after treatment.Results:1) The quality of life in both of the two groups after treatment were improved compared with that before the treatment and the increase of the observation group was more apparent compared with the routine treatment group, which showed statistically significant differences (P<0.05). 2) The cervical mucus TNF-α protein expression levels of the two groups were similar before treatment, and the protein expression reduced in both of the two groups after intervention, the down-regulation in the observation group was more obvious. 3) The cervical mucus IL-2 expression levels of the two groups were close before the treatment, but the concentration of cervical mucus IL-2 increased in both of the two groups after intervention, while the increase in the observation group was more obvious.Conclusion:Honghua Ruyi Pill has ideal curative effect on pelvic inflammation, and may significantly improve patients′ quality of life. Its mechanism may be related to the reduction of TNF-α and the up-regulation of IL-2 expression.