To investigate the clinical effect of Shoutai II Decoction combined with progesterone on fetal irritability of kidney deficiency pattern. Methods: A hundred and ten patients with fetal irritability due to deficiency of the kidney admitted in the hospital from June 2014 to 2015 September randomly assigned for the control group and the observation group with 55 cases in each. Patients in the control group were treated with progesterone intramuscular injection and the observation group was additionally treated with Shoutai II Decoction. The clinical efficacy of the two groups was compared and the main TCM syndrome score was evaluated. The changes of serum hormone level before and after treatment were monitored. Results: The effective rate of the observation group was 90.9% higher than that of the control group (74.5%) (P<0.05); symptoms like backache, abdominal pain, abdominal straining, vaginal a small amount of blood and other of the observation group relieved better than those of the control group patients. Syndrome score was significantly lower than that of the patients in the control group (P<0.05). Serum beta hCG and P levels of patients in the observation group were was significantly higher than that of the control group (P<0.05); delivery outcome in the observation group was significantly better than that of the control group (P<0.05). Conclusion: Shoutai II Decoction combined with progesterone in treating patients with irritability of kidney deficiency pattern received good therapeutic effect and may significantly improve the clinical symptoms and improve the success rate of miscarriage. The mechanism may be associated with increased serum hormone levels and closely related to the Integration of Chinese traditional and Western medicine, which is worthy of clinical popularization and application.