To investigate the therapeutic effects of focused ultrasound combined with traditional Chinese medicine in the treatment of non-neoplastic epithelial disorders of the vulva．Methods: A clinical observation was carried out in 400 patients with non-neoplastic epithelial disorders of the vulva from January 2012 to November 2014. Patients were divided into two groups and one group were treated by focused ultrasound + traditional Chinese medicine (group A, n=200), the other only by focused ultrasound (group B, n=200). Clinical effects were evaluated between the two groups．Results: The complete remission rate and total effective rate of group A were 46% and 96% respectively, which were better than those of the group B (28%, 87.5%). The improvement of pathological lesions in patients who were treated by traditional Chinese medicine assisted with focused ultrasound therapy was more significant. Conclusion:Focused ultrasound combined with traditional Chinese medicine may enhance the results of genital lesions and effectively improve local blood vessels and peripheral nerve function.