To investigate the effects of Panax Notoginseng Saponins (PNS) on the neurological function and cerebral water content in the rats with cerebral hemorrhage. Methods: A total of 350 healthy homologous male SD rats, 230~250 g, were randomly divided into control group, model group and treatment group, and were observed at the following time points: 6 h, 24 h, 48 h, 72 h and 7days respectively. Rats model was established by Ⅳ collagenase type uniform slowly into the tail putamen hemorrhage. The treatment group were given intraperitoneal injection of PNS once a day. The Modified Neurological Severity Score (mNSS) of each group at the same time points was used to evaluate the nerve damage. Results: The mNSS of model group was significantly higher at every time point than the control group (P<0. 05). Except for 6 h, the mNSS of treatment group was significantly higher at the other time points than the other two groups (P<0. 05). The brain water content of the model group was significantly higher at every time point than the control group (P<0. 05). Except for the 6 h and 7d time point, the brain water content of the treatment group was significantly lower than the other two groups (P<0. 05). Conclusion: In the cerebral hemorrhage model groups, the mNSS and brain water significantly increased at 6 h, reached a peak at 48 h, then gradually declined. PNS can significantly decrease the mNSS scores and brain water content.