To observe the curative effect and part of the mechanism discussion of electric arrowhead needle propagated sensation along channel in the treatment of migraine.Methods:Eighty cases of patients with migraine in our hospital during January 2014-January 2015 were included in the study，randomly divided into the conventional group and the observation group，40 cases in each group.The conventional group used electric arrowhead needle with non-acupoint，the observation group used electric arrowhead needle propagated sensation along channel，1 time/day，30 min/time，5 times a week，both of the two groups had continuous treatment for 4 weeks，at the time of the 2nd week，the 4th week after the treatment，compared the two groups of patients with migraine attack frequency，headache days，McGill scores，Anxiety and depression self rating scale score，contemporary compared BDNF concentration changes before and after treatment of the two groups.Results:1)2 weeks after the treatment，both of the two groups of patients with migraine，McGill scores were with obvious reduction，the headache days were shortened，the various indicators of the two groups were with no statistical differences(P>0.05);2)4 weeks after treatment，the indicators in both the two groups continue improved，the improved trend of the observation group were significantly than the control group(P<0.05).3)Peripheral blood concentrations of BDNF in the patients of the two groups were significantly decreased after treatment，the downward trend in the observation group was more obvious(P<0.05).Conclusion:Electric arrowhead needle propagated sensation along channel can obviously improve the symptoms of migraine，and with obvious persisitency effect，this may be related to the reduction of BDNF in the patients.