To analyze the causes of adverse reactions of traditional Chinese medicine(TCM) preparation and to formulate the corresponding preventive measures. Methods: A retrospective analysis was made on 230 cases of adverse drug reactions reported in TCM preparations during January 2014 to December 2015. The patient′s gender, age, reporter′s identity, forms of TCM preparation, pathway of administration, occurrence time, relevant organ and clinical manifestations were recorded and analyzed. Then establish corresponding preventive measures. Results: 1) The incidence of adverse reactions in male patients is higher than that of female patients, but the difference is not statistically significant (P>0.05); 2) The most risky age of adverse reactions is around sixty; 3) Doctors take the largest percent in reporters and pharmacists take the least; 4) Intravenous injection correlates to the highest percentage of adverse reactions, higher than that of oral, intramuscular and other pathways of administration, with P<0.05; 5) Adverse reactions of injection often happen within 30 minutes and other forms of preparations occurred within 1-24 h; 6) Skin and adnexa are the mainly affected organs. Conclusion: Adverse reactions caused by TCM preparation has obvious characteristics. In light of the adverse reactions in different age, dosage form, pathway of administration, corresponding measures can be formulated, which will effectively prevent and reduce the incidence of adverse reactions.