To explore the Chinese Medicine syndromes differentiation and treatment principles of swelling diseases in Clinic Guideline of Medical Records through data excavation. Methods: The symptoms, syndromes, treatment and Chinese medicine treatment principles were excavated via noise suppression and data slicing algorithm based on sensitive keywords frequency statistics method, which was showed by two-dimensional network diagram. Results: The main syndromes of swelling diseases in Clinic Guideline of Medical Records involved abdominal distension and fullness and stool abnormity. Regulating spleen, stomach, liver, lung and kidney was a characteristic of Clinic Guideline of Medical Records. Herbs with pungent, bitter and sweet taste, such as Glabrous Greenbrier Rhizome, White Atractylodes Rhizome, Officinal Magnolia Bark, Dried Tangerine Peel were used frequently. Conclusion: Clinic Guideline of Medical Records emphasizes on the relation among spleen, stomach, lung and kidney, as well as regulating the balance of qi, water and blood. It is practical and scientific to classify the treatment principles on Chinese medicine classics via data excavation.