Professor Jiang Jian is good at using Jiupo Decoction and Zhijing San or the main herbs of them to treat moderate to severe headache induced by internal damage,and the curative effect is remarkable.This paper not only introduce Professor Jiang Jian’s clinical experience,but also discuss whether to use guiding drugs or not.At the same time,the method of flexibly use syndrome differentiation and treatment in treating stubborn headache is discussed.