Since penicillin was discovered, antibiotics have been widely used in clinical and make great contribution to human health and their life, but also have a growing problem: bacterial resistance. The application Chinese material medica enjoys a long history of thousand years in China, and there has not yet been found any obvious drug-resistance bacteria. Thus its effect is proved. It still remains great capacity in development and utilization of traditional Chinese medicine for solving the problem of bacterial resistance. This paper is a summary of the status quo of drug resistance of bacteria and the results of researches and studies on anti-drug-resistant strains of Chinese herbal compound, single herb and monomer in order to provide reference for the clinical treatment and the development of new traditional Chinese Medicine.