As the unreasonable application of antibiotics, the bacterial resistance rate is getting higher and higher, especially the pseudomonas aeruginosa, which was the main pathogenic bacteria in infectious diseases, and this was not only the difficult problem of clinical acute and severe diseases but also the trouble and focus internationally. Therefore, the resistant mechanism research progress of pseudomonas aeruginosa in the recent five years were reviewed. The main resistant mechanism of beta lactamase, active efflux system and quorum sensing system were focused on, and the relevant Traditional Chinese Medicine treatment were detailed, in order to provide a basis for exploring the Traditional Chinese Medicine treatment when antibiotic treatment has no efficacy.