To evaluate the effects of YangXinShi tablets on coronary heart disease angina pectoris together with anxiety neurosis. Methods:A total of 86 patients who were diagnosed as coronary heart disease angina pectoris together with anxiety neurosis in the hospital were randomly divided into YangXinShi group (conventional western medicine and YangXinShi tablets treatment) and control group (conventional western medicine treatment),43 cases in each group treated for 12 weeks. After treatment,the clinical symptoms of angina pectoris,LVEF,hs-CRP,NT-proBNP,HAMAand adverse reactions of all patients were detected. Results:After treatment,1) the total effective rate of improving angina pectoris in YangXinShi group (95.35%) was higher than that of the control group (83.72%) and the difference was statistically significant (P<0.05); 2) the LVEF in YangXinShi group (55±7.4)% was higher than that of the control group (51±5.4)%,P<0.05; 3) the hs-CRP in YangXinShi group (1.07±0.21) mg/L was lower than that of the control group (1.32±0.23) mg/L,P<0.05; 4) the NT-proBNP in YangXinShi group (573±122)ng/L was lower than that of the control group (807±138)ng/L,P<0.05; 5) the HAMA average score in YangXinShi group (7.5±1.6) was lower compared with that of the control group (13.8±2.9),P<0.05; 6) the incidence of adverse reactions in YangXinShi group (2.32%) was lower than that of the control group (18.60%),P<0.05.Conclusion:YangXinShi tablets together with western medicine on coronary heart disease angina pectoris complicated with anxiety neurosis was better than the conventional western medicine treatment.